2025 NFL Odds: Thanksgiving Parlay, Week 13 Predictions, Picks

2025 NFL Odds: Thanksgiving Parlay, Week 13 Predictions, Picks

FOX Sports Research is rolling out a special Thanksgiving parlay built around the four NFL games on the holiday slate, giving bettors a fun way to spice up their turkey-day viewing.

The lineup of games offers no shortage of angles — explosive offenses, rivalry tension and favorable matchup trends, creating a path for bettors to chase a long-shot return with real upside.

The parlay below blends against the spread (ATS picks), Over/Under totals and player props, each selected to match current form and data-driven expectations. It’s a strategic gamble for anyone ready to pair football insight with a bit of daring, knowing that if every leg falls into place, a modest wager can quickly become a headline-worthy payout.

The four legs below come out to a parlay with odds of +1470, meaning a $20 wager would have a total payout of $314.08. Odds were provided from DraftKings Sportsbook as of Nov. 26. 

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

LIONS -2.5 (-115) @ Packers

Chiefs @ Cowboys OVER 52.5 (-110)

Ja'Marr Chase Anytime TD (-120)

A.J. Brown Anytime TD (+140)

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